Reproduce S66x8 CCSD(T)/CBS noncovalent interaction energies with an affordable method to MAE < 0.3 kcal/mol

The S66x8 benchmark provides CCSD(T)/CBS reference interaction energies for 66 biologically-relevant noncovalent dimers (hydrogen bonds, dispersion-dominated stacks, and mixed complexes), each sampled at 8 intermolecular separations scaled around the equilibrium distance (0.90 to 2.00x), for 528 dimer geometries total. Choose an affordable method runnable on a workstation, one of: a dispersion-corrected DFT functional (e.g. wB97X-V, wB97M-V, r2SCAN-D4 with a counterpoise or large basis), the semiempirical GFN2-xTB method, or a foundation ML interatomic potential (e.g. the openly released MACE-OFF family), and compute the interaction energy $\Delta E = E_{\text{dimer}} - E_{\text{A}} - E_{\text{B}}$ for all 528 geometries. Report the mean absolute error (MAE) and RMSD against the S66x8 CCSD(T)/CBS references (kcal/mol), broken down by the three interaction classes and across the 8 distances. Which affordable method reaches MAE below 0.3 kcal/mol, and where along the dissociation curves does it fail most?

Acceptance. FULLY RESOLVES: interaction energies for all 528 S66x8 geometries from one clearly specified affordable method (functional+basis+dispersion, or the exact MLIP/semiempirical model and version), giving overall MAE $\le 0.3$ kcal/mol vs the CCSD(T)/CBS references, reported with the per-class and per-distance error breakdown, counterpoise/basis settings, and a runnable script plus raw energies. PARTIAL: a full reproducible S66x8 evaluation for any such method with its MAE/RMSD (even if above 0.3 kcal/mol) and the error analysis, or a documented result that a named method systematically fails at a specific distance regime. Metric: MAE and RMSD of $\Delta E$ in kcal/mol over the 528 geometries.